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BDNF signaling is known to regulate ARC expression through the ARC SARE site located ~7.7 kb upstream of the transcription start site 22,23 and is regulated by enzymes involved in epigenetic modulation 22,23 , and therefore we examined if there were epigenetic changes at this location (Fig

And so the holy grail of what people have always looked for with stem cells were could we, for lack of a better term, fuck with these cells enough in a petri dish to create pluripotency where they can become something but prevent tumorgenic behavior, where they don't become a tumor or don't become a cancer

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Hamity, M

16 On the other hand, both pancreatic cancer cells and endothelial cells express the HGF receptor, c-MET

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