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ROS cause lipid peroxidation, protein oxidation, and DNA damage, leading to cellular dysfunction and apoptosis

This suggests that under T2 stressed conditions, increases in SLC7A11 activity help maintain intracellular redox balance (Figure 3G)

doi: 10.1128/JVI.79.12.7819-7826.2005 50 SpinettiGBernardiniGCamardaGMangoniASantoniACapogrossiMCet al

Stimuli-responsive platforms for on-demand drug release and microenvironment remodeling Generally, the release dynamic curve of a drug delivery system is static and unchanged upon stimuli thus causing failure of administered drug to be released upon demand and therefore discovering the drug carriers that contain fine tunable properties including tunable pore structure, surface chemistry, bioavailability, and degradability, is extremely considered advantageous when considering improving the site-specific release of drugs

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For example, anti-inflammatory drug stored in pH-sensitive nanoparticles that can only break and release their carrying antioxidant in the microenvironment of tumours, which are known to be lower in pH than normal tissues in many cancers [301]