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High-dose B12 supplements, even 1,000 mcg daily, are generally safe because the body uses what it needs and excretes the rest

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Transcriptional profiling of the murine intervertebral disc and age-associated changes in the nucleus pulposus

Compared with control animals, there was strong upregulation of Nos3, slight upregulation of Nos1, and suppression of Nos2

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These animal studies provide substantial evidence on the promise of both vaccines in addressing the dual challenge of COVID-19 and influenza which formed the basis for their subsequent success in human clinical trials
