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To understand mediators of cagrilintide action, we generated a transcriptomics atlas of over 530,000 cells comprising 80 neuronal cell populations across rat, mouse and macaque caudal brainstem, with spatial profiling to map distribution in the rat dorsal vagal complex (DVC)

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In intestinal Caco-2 cells, MLCK expression, which has an important role in TJ regulation, was interrelated with the TNF--induced barrier defect