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The choice usually comes down to whether KPV's anti-inflammatory mechanism is part of the research interest

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Studies have shown Astaxanthin may trigger reductions in blood sugar and generalized inflammation which results in an overall improvement in heart health and reduction in cardiovascular risk 3, 23 , 26 , 27
Simon SJ, Patell R, Zwicker JI, Kazi DS, Hollenbeck BL

The researchers reported improvement in more than 80% of the patients, but there was no control group

The Ottawa Hospital Sterne JA, Hernn MA, Reeves BC et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomized studies of interventions