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Nrf2-Keap1-ARE-NQO1 signaling attenuates hyperoxiainduced lung cell injury by inhibiting apoptosis

When ingested as a nutritional supplement preferably in the racemic mixture form, LA contains two isomers (1:1 of R-LA and S-LA), in which S-LA may prevent polymerization of R-LA and thus increases the bioavailability of the later (De Araujo et al., LA is found in both vegetable and animal-based foods, identified as lipoyl-lysine (coupling of LA to specific lysine residues

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59 MiR-181a-5p inhibits the 3-UTR activity of -catenin and TCF4, thus reducing the expression of cyclin D1 and AXIN 1, target genes of the Wnt/-catenin pathway, and plays a tumour suppressor role in CRC
Several other cell types under inflammatory conditions have also responded to sulforaphane to downregulate the expression of pro-inflammatory cytokines [147,148,151,155]
