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44,45 The coordinated activity of MCTs establishes lactate transport between glycolytic and oxidative cells, serving as a critical determinant of lactate homeostasis across tissues

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( A ) Diagram showing the design of the BRET assay to measure binding of Nluc-fused peptides to active (QL mutant) or inactive (WT) G subunits fused to YFP

doi: 10.1002/pro.5560060216

Originally studied in Eastern Europe, it has been associated with the regulation of melatonin production, normalization of circadian rhythms, and activation of telomerase

There are two main mechanisms of action for LDN that have been identified