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Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence

Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M

Free Radical Research, 40 (5), 445453

Moreover, dietary supplementation with TMAO significantly decreased the expression of both enteral cholesterol transporters Niemann-Pick C1-like1 (Npc1L1), which transports cholesterol into enterocytes from the intestinal lumen, and ABCG5/8, which transports cholesterol out of enterocytes into the gut lumen ( The TMA/FMO3/TMAO pathway driven by gut microbiota is also an important regulator of lipid metabolism (Warrier et al., 2015)

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30 Next, NADPH is a coenzyme for anabolic enzymes in the synthesis of fatty acids and cholesterol, and is thus the key for the generation of new building blocks that sustain cell growth and proliferation