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And it'll be repaired by itself

Active efflux leads to heterogeneous dissipation of proton motive force by protonophores in bacteria
Characterization of the surface immobilized synthetic heparin binding domain derived from human fibroblast growth factor-2 and its effect on osteoblast differentiation
As a result, oxygen supply to your body reduces, making you feel weak and low on energy

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Hence, targeting both of them simultaneously might be a promising approach to hinder therapeutic resistance by blocking all potential alternative routes