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Pramlintide (approved 2005): three-amino-acid substitution enabling solubility, 2-3 daily dosing before meals, approximately 23% weight loss in T2D

10.1038/nrd.2015.21 Nat

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167,168 A double-blind controlled trial enrolled 55 older women with type 2 diabetes and randomized them to receive either 200 mg pyridoxamine twice daily or placebo for one year

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