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It is conceivable that this general mechanism can explain Mercury-induced oxidative stress not only through a continuous depletion of the reduced glutathione pool, but also by interfering with enzymes operating through active sites based on vicinal thiol groups or which are regulated by glutathionylation of sensing cysteine residues

However, sublingual bioavailability for peptides is inherently lower than subcutaneous injection because the oral mucosa presents a significant absorption barrier for large molecules

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Therefore, inhibition of glutamine metabolism is suggested as a therapeutic method to prevent the growth of leukemia cells

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