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To rule out a possible toxic effect on the NuAc of the BSO dose used, we performed an activated caspase 3 (a marker of the execution-phase of cellular apoptosis) and neuroN (a marker of mature neurons) staining assay on accumbal sections from a subset of animals tested in the PR test (Supplementary Figure 3 i-l)

The combination therapy increased water intake, as did sCT (Supplementary Figure 3B, I)

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It gradually fades hyperpigmentation and brightens the overall skin tone