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Ajani JA, Faust J, Yao J, Komaki R, Stevens C, Swisher S, Putnam JB, Vaporciyan A, Smythe R, Walsh G, Rice D, Roth J

Recent preclinical data indicate that intermittent or adaptive dosing schedules significantly prolong therapeutic effectiveness compared to continuous drug administration by disrupting metabolic and epigenetic adaptations critical for DTP survival (Kruk and Schwalbe, 2006

Protein precipitation using methanol (Merck KGaA, Darmstadt, Germany) and 0.1% formic acid (Merck KGaA, Darmstadt, Germany) was performed and the collected supernatant was treated with a derivatization solution of aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) (Merck KGaA, Darmstadt, Germany)

Int J Mol Sci 23(1):280

Furthermore, RJ contains free amino acids such as methionine, proline, cysteine and cystine might responsible for this effect by promoting biosynthesis of glutathione and scavenging free radicals, in addition to the ability of RJ to enhance the activity of antioxidant enzymes 35

Selenium deficiency is a well-recognized risk factor for KDB [205]