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Description
However, when GPX4 mito was down-regulated with GPX3 knockdown, the expression level of DHODH in mitochondria increased, whereas GPX3 overexpression did not affect it

GSH serves as a cofactor for several detoxification enzyme (e.g., glutathione peroxidase: GPx), assists in the transport of amino acids through the plasma membrane, and is able to regenerate the C- and E-vitamins and direct scavenger of OH and singlet oxygen (47)
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