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In the foregoing synthesis method of cagriltide, the specific step of cyclization in step four includes: dissolving the linear peptide crude product in acetonitrile water according to the dose that 1g of the linear peptide crude product is dissolved in 100mL of 50% acetonitrile water solution, adding purified water to dilute the linear peptide crude product to 1g/L after the linear peptide is dissolved

As demonstrated by the chick chorioallantoic membrane (CAM) assay and endothelial tube formation assay, BPC 157 could increase the vessel density both in vivo and in vitro, respectively

[4] Eli Lilly and Company

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