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Evidence ranges from early laboratory work to clinical trials depending on the use the sections below cover the actual data and sources

Maternal FRAAs during pregnancy have been associated with increased risk of neural tube defects and adverse neurodevelopmental outcomes in animal models, suggesting that in utero FR blockade may perturb early patterning and later circuit formation [69, 70, 93]

Tummers QR, Hoogstins CE, Gaarenstroom KN, de Kroon CD, van Poelgeest MI, Vuyk J, et al

10.1039/D1FO03746C

In fact, the levels of several of the metabolites in the TSP and OCM pathways differed between individuals with ALD, active drinkers without liver disease, and healthy controls

Oxidative stress and Parkinson's disease