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The study involved 130 ALS patients (74 men and 56 women) whose symptoms began within one year of enrollment and who progressed at a moderate rate, defined as a 12 point decrease in their ALSFRS-R scores over the three months preceding the trial

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IGF-1 treatment: future and limitations The FDA approved the use of rhIGF-1 (Mecasermin, Increlex) for treatment of severe primary IGF-1 deficiency in 2003