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While many studies show that chronic (several day) exposure during development induces morphological, behavioral, and genomic changes, very few have examined the effect of a brief exposure and/or the impact of a recovery/washout period on assessed outcomes

In models of Parkinsons disease, treatment with EGCG inhibited -synuclein aggregation [244], prevented the decrease in dopamine [245,246], and reduced neuronal cell death that was associated with inhibition of iNOS [247]

The resulting extracts were analysed by ultrahigh performance liquid chromatographytandem mass spectroscopy (UPLC-MS/MS) using a Waters ACQUITY ultra-performance liquid chromatography (UPLC) and a Thermo Scientific Q-Exactive high resolution/accurate mass spectrometer (MS) interfaced with a heated electrospray ionisation (HESI-II) source and Orbitrap mass analyzer operated at 35,000 mass resolution 60

However, contradictory findings were obtained in a recent study which concluded that mutant TDP-43 A315T does not impair mitochondrial bioenergetics in vitro and in vivo (Kawamata et al., 2017)

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