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This is because it is water-soluble, so most ingested B12 is actually flushed out in the urine

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A blood test is an indication for how much the brain might have access to B12, but if for instance the blood-brain barrier does not absorb enough B12, the brain will have too little B12, while the blood test is normal

Furthermore, proteomic analysis supports these observations at the molecular level, with enhanced cellular recycling processes like proteasome enhancement, as well as protein synthesis upregulation, needed to rebuild nerve connections and combatting oxidative stress

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