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In a controlled colesevelam trial in 30 patients with IBS-D, colesevelam did not alter mucosal permeability (179)

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Though the results are controversial, as iron nanoparticles have no effect on the microbiota, zinc (Zn)-nanoparticles can have some beneficial effects, and other components such as silicon dioxide (SiO 2 ) nanoparticles may cause IEB disruption

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also known as PTP1D, SYP, SH-PTP2, and SH-PTP3) has ubiquitous expression