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Our findings indicate that the loss of dopaminergic neurons would start a vicious cycle of decreased dopamine releaseDRD2 signaling deficiencydecreased GSH synthesisoxidative stressdopaminergic neuron death during the progression of PD and explain the mechanism by which GSH decreases in the brains of PD patients (Supplementary Fig

B-5 Vitamin B5 is a component of coenzyme A (CoA)

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Lancet Neurol 12: 105118, 2013

Cellular lipid ROS assay Lipid ROS levels were measured through oxidation of the C11-Bodipy lipid peroxidation sensor (Thermo Fisher Scientific) according to the manufacturers instructions