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SUMMARY The invention provides small molecule mimetics (mimic) of the growth factor "hepatocyte growth factor" (HGF) that are orally active, display profound growth factor activity, and are inexpensive to synthesize

Where required initial treatment is with chemotherapy with radiotherapy reserved for teenagers and younger children who have not responded to chemotherapy

Half-Life and Duration of Effects An important and often misunderstood aspect of Dihexa pharmacology is the distinction between blood half-life and clinical duration: Blood Half-Life Dihexa's blood half-life is estimated to be relatively short (minutes to a few hours), though precise human data are lacking

The Cys32 residue is also the target for S -sulfhydration (Aroca et al