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3) Others In mice white blood cell (macrophages), the cytokine IFN-gamma increased glucocorticoid receptors [29] Ginsenosides (from ginseng) increased the binding activities of glucocorticoid receptors in mice brain, lung, and liver cells [30] Chronic lithium chloride injection increased glucocorticoid receptor production (mRNA expression) in rat brains [31] Factors That Decrease Glucocorticoid Receptor Activity 1) Natural Substances High vitamin B6 concentration suppressed glucocorticoid receptor production, while its deficiency enhanced the bodys responsiveness to glucocorticoids, in rats and cells [32]