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Given that cardiomyocyte hypertrophy and interstitial fibrosis are the core pathological features of RV decompensation in PH, it is highly plausible that the dysregulated lactate-lactylation axis acts as a critical, yet underexplored, pathological driver in this progression

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[DOI] [PubMed] [Google Scholar] 267.Turhan Y., Arcan M., Karaduman Z.O., Turhal O., Gamszkan M., Aydn D., Kl B., zkan K

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ROS, which include superoxide anion, H 2 O 2 and hydroxyl radicals, have been copiously considered early mediators of autophagy upon nutrient deprivation 17,29