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Sivanesan I, Muthu M, Gopal J, Oh JW (2022) Mushroom polysaccharide-assisted anticarcinogenic mycotherapy: reviewing its clinical trials

An in vitro study demonstrated that Ginsenoside Rb1 reduced the production of reactive oxygen species, inhibited JNK activation, increased Bcl-xL levels, and decreased the levels of Bax, cytochrome c, caspase-3, and cleaved poly-(ADP-ribose) polymerase in gentamicin-treated VOT-E36 cells

10.1007/s11064-023-03887-y 104 ShreeB.KumarS.SharmaS.KatochV

10.1186/s13045-020-00979-y 46 LeiX.DuL.YuW.WangY.MaN.QuB

Implicated specifically were increased angiogenesis, elevated vascular endothelial growth factor (VEGF) levels, upregulation of the early growth response (egr-1) gene, enhanced nitric oxide (NO) and NO-synthase (eNOS) stimulation, and counteraction of increased free radical formation [1]

Clinical evidence from the last 5 years shows positive signals from improved muscular and metabolic performance with NAD, to neuroprotection and cutaneous improvement with GSH while still requiring confirmation from larger, controlled studies