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The development of nanotechnology-based formulations, such as liposomes and nanophytosomes, has shown great promise in enhancing the solubility, stability, and brain bioavailability of these compounds, thereby maximizing their neuroprotective effects in ASD ( However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro ( Weight of evidence: Overall evidence is LowModerate : robust mechanistic plausibility and diverse preclinical benefits

SCORE-OP estimates risk in individuals 70 years and older, and SCORE- Diabetes estimates risk in individuals with diabetes

Briefly, 10 10 6 bone marrow cells were cultured in a 10-cm petri dish for one week in DMEM (Life Technologies) supplemented with 10% FBS (Life Technologies), 1% penicillin and streptomycin (Life Technologies), and 20% L929 conditioned media (79)

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Classification of the identified active ingredients Labels of products categorized as supplements supporting cognitive functions were analysed for active ingredients