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Description
10.1186/s13229-021-00472-4 49 EmanueleE.OrsiP.BosoM.BrogliaD.BrondinoN.BaraleF.et al (2010)

Phage selection of bicyclic peptides

54 Lipoxygenases (LOXs) are dioxygenases that catalyze the peroxidation of PUFAs to produce various lipid peroxides and bioactive lipids in the presence of molecular oxygen

Results Here we show that peptides 17-mer and H105A delivered via eye drops successfully reach the retina, promote photoreceptor survival, and improve retinal function in both RP mouse models

However, it also implies that therapeutic drugs need to be specially designed (combining targeted drugs with immunosuppressants) to prevent unnecessary inflammation or immune reactions

This mechanism is restricted to plant tissue and enhances plant tolerance during oxidative stress (Krasnovsky, 1998)
