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Vomiting is a common symptom in cats with CKD, and can become even more frequent due to issues such as pancreatitis

Furthermore, DAG generated by PNPLA2 preferentially produces 1,3- DAG which cannot activate PKC (196), suggesting that the de novo generation of DAGs leads to insulin resistance

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From the cardiovascular system: tachycardia, arrhythmia, bradycardia, transverse heart block, cardiac arrest, peripheral vasodilation, collapse, pain in the heart, increased or decreased blood pressure, slowed heart conduction