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As an experimental system we used a human BBB co-culture model improved by cARLA

Repetitive apneas as observed in SA syndrome are associated with increased diurnal drowsiness, neurocognitive dysfunction, and cardiovascular morbidity (Young et al., 2002

Deteriorating muscle strength and function as we get older lead to debilitating conditions like frailty, which can be life threatening

This study was supported by Grants NIH R35GM141478, VA 1I01BX004639 and VA I01BX006408 (to X-AL)

Permeabilization and blocking was performed by adding PBS (Lonza) containing 0.1% saponin (Carl Roth) and 3% normal donkey serum (Abcam, Cambridge, UK) for 30 min at RT

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