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In addition, studies were identified from the reference lists of obtained published articles, editorials and known studies

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Peptide-based therapies in modern medicine: Opportunities and challenges

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To lift the barrier, the cytosolic loops in SRD5A2 may undergo conformational changes during the reaction so that the cytosolic region can open up to expose the nucleotide-binding pocket to the cytosol before and after one reaction to allow NADP + /NADPH exchange, and thus efficient reaction turnover

Which types work, how to use them, and clinical evidence