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Individuals who are pregnant, breastfeeding, or managing certain medical conditions (such as kidney disease or specific vitamin sensitivities) should consult with their physician first

The four subcutaneous areas that work best are the lower abdomen (away from the navel), the outer thigh, the back of the upper arm, and the flank or love-handle area

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Long-Term Safety Considerations: While safety data from clinical trials spanning up to 24 weeks is reassuring, long-term safety data spanning years of continuous use remains limited

The MHRA and EMA have not identified histamine intolerance as a recognised adverse effect, though gastrointestinal symptoms from both conditions may overlap
