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This finding has important safety implications, as elevated IGF-1 levels associated with full GH therapy raise concerns about increased cancer risk, particularly for individuals with pre-existing malignancies or strong family histories

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Nuclear nicotinamide adenine dinucleotide deficiency by Nmnat1 deletion impaired hepatic insulin signaling, mitochondrial function, and hepatokine expression in mice fed a high-fat diet

Dosing for confirmed deficiency: 500 to 1,000 mcg per day orally

[PubMed | ClinicalTrials.gov | DOI] Wadden TA, Bailey TS, Billings LK, et al