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[PUBMED Abstract] Tarhini AA, Lee SJ, Hodi FS, et al.: Phase III Study of Adjuvant Ipilimumab (3 or 10 mg/kg) Versus High-Dose Interferon Alfa-2b for Resected High-Risk Melanoma: North American Intergroup E1609

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TMAO is thought to protect against urea buildup and also mitigate the effects of pressure (useful for fish under the sea, not so useful for us), and interestingly it is the breakdown of TMAO into TMA (trimethylamine) which gives rise to that distinctive seafood smell