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Articles pertinent to the aim of the review were selected based on the relevance of the title and abstract in the topic by four authors (R.M.R., E.M., L.C., and C.V.) and then were critically evaluated by all authors

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For example, sphingosine-1 phosphate inhibits apoptosis induced by ceramide, a well-established inducer for both apoptosis and autophagy, but induces autophagy 46

Metastasis LPA promotes metastasis across multiple cancers by integrating proinvasive, prosurvival, and TME-remodeling mechanisms

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