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[PubMed 19834803] 3577

Although genetic methods (i.e., gene knockout and knockdown) are powerful approaches, they often activate compensatory pathways, making it difficult to determine the specific role of each enzyme (Marutani and Ichinose, 2020

C th c s dng trn c th, chng hn nh khuu tay v u gi, ni mu da khng ng u

Furthermore, increased strand breaks generation caused activation of poly(ADP-ribose) polymerase (PARP), a zinc finger DNA-binding protein, known to deplete intracellular NAD + reserves as well as energy stores, thus ultimately resulting in cell death (429)

Glutaminolysis is a metabolic dependency in FLT3(ITD) acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

doi: 10.1093/toxsci/kfl175