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3 Mechanisms of neurotrophin-driven tumorimmune remodeling Neurotrophin signaling reprograms the osteosarcoma microenvironment through coordinated actions on myeloid trafficking and polarization, antigen-presenting cell function, endothelial activation, and neuronimmune circuits that collectively degrade antitumor effector quality

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Neuroimmune coupling via sensory pathways further reinforces myeloid predominance and T-cell dysfunction in bone tumors, suggesting that neurotrophin gradients contribute to immune exclusion and impaired effector quality (8486)

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