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Metformin (1,1dimethylbiguanide hydrochloride) is a widely used antidiabetic agent that decreases insulin resistance and lowers blood glucose levels through the inhibition of liver glucose production and an increased glucose uptake in muscles 10,11

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Misregulation of the immune response may lead to a massive increase of cytokine and chemokine levels which is referred to as cytokine release syndrome or cytokine storm
