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Additionally, LAT1 facilitates the transport of CNS-active drugs, such as melphalan [79], levodopa (L-Dopa) [80], gabapentin [81], and pregabalin [82], making it integral for developing prodrugs with enhanced BBB permeability [83]

Melatonin also acts in another molecular mechanism of cell death dependent on mitochondria, which is associated with the elevation of intracellular Ca 2+ concentration [171,176]

Mancilla, H

IGF-1, or Insulin-like Growth Factor-1, is a natural protein made up of 70 amino acids

Obeticholic acid modulates serum metabolites and gene signatures characteristic of human NASH and attenuates inflammation and fibrosis progression in Ldlr-/-.Leiden mice

For each significant effect we calculate the Cohen's d in order to demonstrate the effect size