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Many weight loss methods, including GLP-1 medications like semaglutide and retatrutide , lead to unintended loss of lean mass

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This happens because certain MTHFR mutations (C667T and A129C) lower the amount of active folate being produced in the body, and the use of vitamin B12 requires the active form of folate

Patient-reported outcome measures specific to the diagnostic process should be developed and validated

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And they're at higher risk for atrophic gastritis
