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Targeting macrophage plasticity through CCR2 inhibition or PPAR agonists shows therapeutic potential by reducing both inflammation and fibrosis in preclinical models (57)

Hyperoside inhibits excessive hypoxia and reduces autophagic death of granulosa cells by regulating the HIF-1/BNIP3 pathway, consequently decreasing the loss of primordial follicles and follicle atresia, thus improving ovarian reserve function and fertility in mice [108]

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10.1039/d4ra00590b 45 LanjuX.JingX.ShichangL.ZhuoY

Alkaloids are naturally occurring organic compounds containing nitrogen atoms