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Strength gains from better energy production

The N171-82Q model, expressing a 171-amino acid N-terminal fragment with 82 CAG repeats, shows slower progression (symptoms at 1116 weeks), striatal neurodegeneration, and better modeling for adult-onset HD (McBride et al

doi: 10.1111/nph.15123 171 TakahashiM.ArimuraG.-I.MorikawaH

Modulating the protein corona provides an alternative strategy to enhance brain-targeted nanomedicine beyond conventional surface chemistry approaches
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Conversely, the neuroprotective KYNA has limited permeability, underscoring the importance of its in situ synthesis within the CNS for its neuromodulatory functions
All other chemicals and reagents were of analytical grade, and the water was glass-distilled