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In addition to the Leu198Leu genotype in the GPx1 gene, the Ala16Ala genotype in the manganese superoxide dismutase ( MnSOD ) gene, the most significant enzyme that protects against ROS in the human body [90], was also associated with an increased risk of breast cancer [91]

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doi: 10.1002/jnr.22738

Additionally, the genetic defect impairs normal neural crest cell migration into the branchial arches, causing craniofacial anomalies and severe conotruncal cardiac defects (interrupted aortic arch) that may require immediate palliative interventions like balloon septostomy
Lim PJ, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha SR, Armitage AE, Mehta H, Wideman S, Santos AG, et al
86 MojzisJ.NistiarF.KovacG.MojzisovaG
