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Particularly, NPs related senescence has been associated to downregulated endothelial nitric oxide synthase (eNOS), impairing normal vasal motility, as well as increased NOXs and suppressed sirtuin (SIRT)1 expression [74] ( Figure 3 )
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LeroyFSmithNWAdesoganATBealTIannottiLMoughanPJet al
However, more recent, but shorter, studies have not confirmed this result [151]
