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2003, 105 , 586 592, DOI: 10.1007/s00401-003-0688-zGoogle Scholar47Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiformeWolburg, Hartwig

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Most people are b12 deficient due to their diets, especially those on a plant based diet
doi: 10.1080/19490976.2021.1887722 21 CarfA.BernabeiR.LandiF

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For those who are mindful of their health such as through adequate water intake and proper nutrition are likely to experience enhanced effects
