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General Safety Profile Based on the preclinical dataset and the limited human exposure data: No prominent signal of hepatic, renal, or hematological toxicity at tested doses No prominent cardiovascular safety flag Pregnancy and lactation as with most research compounds, safety not established Long-term effects not characterized What Clinicians Should Actually Tell Patients For patients asking about 5-amino-1MQ, a reasonable response framework: What the compound is: A research-stage small molecule inhibiting NNMT with promising preclinical fat loss data

Glass SB, Gonzalez-Fajardo L, Beringhs AOR, Lu X

MET is primarily expressed not only in epithelial and endothelial cells (Gentile et al., 2008) but also in myoblasts and neuronal precursors, contributing to the development of muscle and nervous structures (Bladt et al., 1995

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doi:10.1530/EJE-11-0917 89