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The Q227E mutant, on the other hand, exhibited almost 10-fold reduction in K m for prephenate (2.7 mM), while the catalytic efficiency ( k cat / K m ) was reduced by 60-fold (0.1 vs

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We too found that overall, the frequency of PP and DD divisions was similar when all generations are examined together

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This has been supported by the demonstration of a decrease in serum citrulline in these patients [63]
