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Its primary biological function is to protect cellular machinery from oxidative stress by neutralizing reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide, which are natural but destructive byproducts of cellular energy production

Before introducing the concept of ferroptosis, numerous studies demonstrated how ROS and end-products of lipid peroxidation like MDA damage proteins and DNA, resulting in cell injury (Wang et al., 2011)

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Ibudilast Reduces Oxaliplatin-Induced Tactile Allodynia and Cognitive Impairments in Rats

Cancer Cell 18 , 910 (2010)