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These findings suggested that vitamin B12 alleviated the level of ER stress

Further studies are needed

However, when Pb 2+ compromises enzymes such as isocitrate dehydrogenase and -ketoglutarate dehydrogenase, the pool of -ketoglutarate is depleted, reducing substrate availability for glutamate production via transamination

This specific epigenetic modification activates the transcription of IL-1, IL-6, and TNF-, thereby driving PASMCs toward a pro-inflammatory phenotype

A Phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia

Additionally, studies reveal that Pae enhances Nrf2 protein expression, potentially preventing lipid accumulation in foam cells by reducing ferroptosis