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[DOI] [PubMed] [Google Scholar] Heiman M, Schaefer A, Gong S, Peterson JD, Day M, Ramsey KE, Suarez-Farinas M, Schwarz C, Stephan DA, Surmeier DJ, et al

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But the authors themselves are explicit that this was an in vitro study using human cell lines in 2D cell cultures, that qPCR measures only average telomere length across chromosomes, that only a handful of cell lines were tested, and that human trials remain necessary before clinical application. [2] A single 2025 replication strengthens the cell-biology claim

CREDENCE (Perkovic et al, NEJM 2019, NephJC summary) was the first study to focus on patients at high risk of kidney outcomes and promote those outcomes to the primary end-point

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