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The highlighted region indicates the distinctive triple-proline motif (P3-P4-P5) that confers exceptional structural rigidity and acid stability

Additionally, various molecular techniques, including Western blotting, reverse transcription, quantitative PCR, immunofluorescence, and immunohistochemistry, were utilized to examine the expression levels of angiogenesis-related factors and the Notch/NF-B pathways-related factors

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In some cases, this damage isn't reversible

Oral activity at systemic targets (tendons, bone) is not established in humans
